3D Amplification Breakthrough Enables Ultrasensitive IL-6 Detectio

A novel biosensor design leveraging three-dimensional spatial amplification has achieved an exceptionally low detection limit of 0.27 pg/mL for interleukin-6 (IL-6) in human plasma—significantly advancing diagnostic sensitivity. The device, built using femtosecond laser-fabricated 3D microstructures with over 4,500 microcavities, offers a 13-fold increase in reactive surface area compared to traditional 2D formats. This enhanced surface area, paired with controlled fluid manipulation via pressure and centrifugation, allows for highly efficient antigen-antibody interactions in a miniaturized format. The study positions this 3D IL-6 biosensor as a strong candidate for point-of-care diagnostics, enabling fast, sensitive, and portable inflammatory biomarker monitoring.