Classical Epithelial State and KRAS Inhibition Resistance in Pancreatic Cancer
| Type | research |
|---|---|
| Area | Pancreas |
| Published(YearMonth) | 2411 |
| Source | https://aacrjournals.org/cancerdiscovery/article/14/11/2122/749200/A-Classical-Epithelial-State-Drives-Acute?searchresult=1 |
| Tag | newsletter |
| Checkbox | |
| Date(of entry) |
A study investigating resistance mechanisms to KRAS inhibitors in pancreatic ductal adenocarcinoma (PDAC) has identified a shift to a classical epithelial state as a key contributor to early drug resistance. Through genetically engineered mouse models and patient-derived xenografts, researchers observed that PDAC cells adopt this classical state under KRAS inhibition, creating a reservoir for disease relapse. Targeting the classical state alongside KRAS inhibition improved therapeutic outcomes, highlighting a potential approach to overcome resistance in PDAC treatment.