Distinct Macrophage Populations and Colon Cancer Outcomes
| Type | research |
|---|---|
| Area | Medical |
| Published(YearMonth) | 2403 |
| Source | https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-23-1300/742035/Spatially-Segregated-Macrophage-Populations |
| Tag | newsletter |
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| Date(of entry) |
A study published in Cancer Discovery by Magdalena Matusiak et al. identifies five distinct macrophage populations in colon cancer, revealing their spatial distribution and cellular associations within the tumor microenvironment. The researchers found that IL4I1+ macrophages, which are associated with high cell turnover areas, predict better outcomes, while SPP1+ macrophages, located in hypoxic and necrotic regions, are linked to poorer prognosis. These findings underscore the importance of macrophage spatial heterogeneity in influencing cancer outcomes and potential therapeutic strategies