Enhancing Cancer Immunotherapy with Serine/Glycine-Free Diet

A groundbreaking study explores the dual role of a serine/glycine-free diet (-SG diet) in colorectal cancer (CRC) treatment. Researchers found that this diet not only suppresses CRC growth but also boosts antitumor immunity by increasing cytotoxic T cell activity. However, tumor cells counter this effect through PD-L1 lactylation, a mechanism enabling immune evasion. By combining the -SG diet with PD-1/PD-L1 pathway inhibitors, the function of CD8+ T cells can be restored, enhancing immune responses. A phase I clinical trial confirmed the diet's safety, feasibility, and potential therapeutic impact. These findings suggest the -SG diet, paired with immunotherapy, could revolutionize solid tumor treatments.