Mapping Fibroblast Diversity: Insights into Immune Modulation in Cancer
| Type | research |
|---|---|
| Area | Medical |
| Published(YearMonth) | 2410 |
| Source | https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00319-2 |
| Tag | newsletter |
| Checkbox | |
| Date(of entry) |
This comprehensive fibroblast atlas, derived from single-cell RNA sequencing of 517 human samples across 11 tissues, uncovers the functional diversity and clinical significance of fibroblast subtypes in inflammation and cancer. Pathological conditions reshape fibroblast populations, with immune-modulating fibroblasts expanding during inflammation and specialized myofibroblasts emerging in tumors. Among these, LRRC15+ and MMP1+ myofibroblasts foster immune-suppressive tumor microenvironments (TMEs), promoting cancer progression, while PI16+ fibroblasts in non-cancerous regions exhibit anti-tumor properties. These findings reveal fibroblast subtype-specific roles in shaping TMEs and define patient subgroups with distinct clinical outcomes. The study provides a foundation for developing targeted therapies aimed at fibroblast subtypes to combat cancer and modulate immune responses.