Mapping the Complex Microenvironmental Landscape of Pancreatic Cancer Metastasis
| Type | research |
|---|---|
| Area | Pancreas |
| Published(YearMonth) | 2411 |
| Source | https://pubmed.ncbi.nlm.nih.gov/39294496/#:~:text=Spatial%20transcriptomic%20analysis%20of%20primary,cancers%20highlights%20tumor%20microenvironmental%20heterogeneity) |
| Tag | newsletter |
| Checkbox | |
| Date(of entry) |
A recent study in Nature Genetics utilized spatial transcriptomics to examine the tumor microenvironment in matched primary and metastatic pancreatic ductal adenocarcinoma (PDAC) samples, uncovering significant spatial, cellular, and molecular heterogeneity. Researchers identified distinct spatial "ecotypes" characterized by fibrosis, altered metabolism, and immunosuppression, varying notably between primary and metastatic sites. Notably, the invasive border region exhibited mixed pro- and anti-tumor immune cell enrichment, highlighting potential new targets for immunotherapy. These spatial ecotypes emphasize tumor adaptability and suggest personalized spatial mapping as a crucial step toward individualized treatment strategies in metastatic pancreatic cancer.