Mapping the Early Human Lung: A High-Resolution Protein Atlas

A pioneering study under the Human Developmental Cell Atlas (HDCA) initiative provides the first high-parametric protein-level map of human lung development during the first trimester of gestation. Using advanced imaging with a 30-plex antibody panel, researchers analyzed over 2 million cells from lung samples spanning 6 to 13 post-conception weeks. This resource details the spatial organization of cell types, including proliferative states, immune cell patterns, and their temporal evolution. By offering a single-cell-resolved view of lung development, this atlas sheds light on the foundational processes of respiratory system formation and creates new opportunities for investigating the origins of respiratory health and disease.