Mapping the Plasma Proteome: A New Frontier in Precision Medicine
| Type | research |
|---|---|
| Area | AIMedical |
| Published(YearMonth) | 2411 |
| Source | https://www.cell.com/cell/fulltext/S0092-8674(24)01268-6 |
| Tag | newsletter |
| Checkbox | |
| Date(of entry) |
A groundbreaking study has constructed the most comprehensive atlas of the plasma proteome, analyzing data from 53,026 adults in the UK Biobank over a median follow-up of 14.8 years. Linking 2,920 plasma proteins to 1,706 diseases and health-related traits, the research identified 168,100 protein-disease associations and over 650 proteins shared across at least 50 diseases. Advanced machine learning uncovered biomarkers with high diagnostic accuracy (AUC > 0.80) for 183 diseases, alongside 37 drug repurposing opportunities and 26 promising therapeutic targets with favorable safety profiles. The study’s open-access proteome-phenome resource aims to advance precision medicine by providing tools for biomarker discovery, disease prediction, and therapeutic development.