Proteomics Reveals Key Intercellular Signaling Mechanisms in Pancreatic Cancer
| Type | research |
|---|---|
| Area | Pancreas |
| Published(YearMonth) | 2501 |
| Source | https://pubmed.ncbi.nlm.nih.gov/39537929/#:~:text=Clinical%20functional%20proteomics%20of%20intercellular,signalling%20in%20pancreatic%20cancer) |
| Tag | newsletter |
| Checkbox | |
| Date(of entry) |
A groundbreaking study in Nature employed an advanced proteomic method, termed TMEPro, to deeply profile glycosylated secreted and plasma membrane proteins from human pancreatic ductal adenocarcinoma (PDAC) tissues. This comprehensive analysis uncovered critical intercellular signaling pathways within PDAC's notoriously complex tumor microenvironment (TME). The research identified reciprocal interactions between cancer cells and stromal cells mediated through the PDGFR-PTPN11-FOS axis, alongside a novel signaling mechanism involving AXL receptor ectodomain shedding regulated by matrix metalloproteases. Notably, elevated levels of shed AXL correlated with lymph node metastasis, and inhibiting AXL shedding and kinase activity synergistically reduced cancer cell proliferation. These insights present potential new therapeutic and diagnostic targets for tackling PDAC.