Towards systems immunology of critical illness at scale: from single cell 'omics to digital twins
| Type | review |
|---|---|
| Area | Digital Twin |
| Published(YearMonth) | 2303 |
| Source | https://pubmed.ncbi.nlm.nih.gov/36967340/ |
| Tag | newsletter |
| Checkbox | |
| Date(of entry) |
This review by Yoram Vodovotz delves into the innovative intersection of single-cell 'omics and digital twin technologies in the realm of critical illness research, such as COVID-19. It underscores the transformative insights gained from single-cell 'omics, which, when combined with parsimonious mathematical modeling, offer a nuanced understanding of inflammation and immunity. This integrative approach not only enhances our basic scientific knowledge but also paves the way for translational advancements, including the development of in silico clinical trials and potential strategies for immune system reprogramming. The paper champions the synergy between data-driven and mechanistic modeling, emphasizing its vital role in navigating the complexities of critical diseases.