Unveiling Brain Aging Patterns: Genetic and Clinical Insights

This investigation explores morphological brain changes in cognitively unimpaired individuals, identifying three subgroups with distinct aging patterns. These patterns are linked to specific genetic markers, cardiovascular risk factors, and amyloid pathology, offering new insights into Alzheimer's disease susceptibility and cognitive decline. This research highlights the potential for early patient stratification and personalized treatment approaches in neurodegenerative diseases, emphasizing the importance of genetics and lifestyle in brain health.